The Indo-Pacfic region is home to both a rich cultural and geographic diversity and a unique archaeological record spanning millennia. This record encapsulates several key periods of transformation in human history, providing an unparallelled opportunity to explore human experiences of these transitions across a range of contexts. These transitions include the adoption of agriculture and periods of social change, including the rise of non-egalitarian communities. Bioarchaeological research in the Indo-Pacific region has typically taken a population-level approach to exploring human health and behaviour during these transitions. However, recent research has suggested that population level approaches, though valuable, may obscure variation in lived experiences and prevent insights into questions of global significance that may best be addressed at a more granular scale, such as the role of individual identity and agency in shaping health outcomes and experiences, and how small-scale, everyday actions and interactions produce large-scale social change. This session therefore aims to showcase bottom-up bioarchaeological approaches to the investigation of large-scale transformations in the Indo-Pacific region. We define ‘bottom-up bioarchaeology’ as studies that explore human experiences of large-scale social, economic, or environmental transformations from an individual, group, and/or multiscalar perspective. We particularly welcome researchers highlighting the Indo-Pacific region’s unique contributions to questions of global significance, such as climate change, social inequality, human adaptation, mobility, frailty and mortality, and identity.