The regions of South Asia, Southeast Asia, and Southern China have long been recognized as critical hubs for prehistoric human interactions and agricultural transmissions. Recent archaeological findings have revealed extensive cultural connections through shared lithic, ceramic, and metallurgic technologies. However, due to challenges in biomaterial preservation in tropical and subtropical environments, key questions regarding the early spread of crops and livestock, as well as the significance of major exchange routes such as the Southern Silk Road, remain inadequately understood. This session invites studies that explore cultural, technological, and human population movements across these regions from bioarchaeological perspectives, including but not limited to zooarchaeology, archaeobotany, osteoarchaeology, ancient DNA, proteomics, isotopes and residues. Submissions that employ multidisciplinary approaches and examine the human-animal-plant interactions are particularly encouraged. In addition to presenting new data, we also welcome methodological innovations aimed at overcoming preservation-related challenges in biomolecular research. Ultimately, this symposium seeks to synthesize diverse lines of evidence to better understand the interactions that shaped the populations and cultures of South, Southeast and East Asia, and foster collaborations among researchers working across different regions and disciplines.