Known for its rich cultural and natural heritage, Mae Hong Son province in northern Thailand is a place where a diversity of art forms including fine arts, architecture and sculpture are well-represented. Throughout the history of Mae Hong Son, people have been sharing the idea of social interaction in economic and cultural exchange, especially through music, and as a result the diverse ethnic groups of the province show clear musical identities. Folk music in Mae Hong Son is full of stories illustrating various aspects of people’s lives such as agriculture, rituals and traditions. People recorded stories in the form of music across generations, to understand and remember the roots of the ancient culture in which music always performed this function. This creative research was the musical portion of an interdisciplinary research project entitled “Upgrading Cultural Heritage for Creative Tourism in Mae Hong Son Province”. Four districts were selected for their different cultural and historical characteristics: Pang Ma Pha, pre-historic route; Mae Sariang; Lanna culture route; Mueang Mae Hong Son, Wood trading route; and Khun Yuam, reminiscence of World War II. They served as case studies to explore existing music by using the concept of Cross-Cultural Progress in Music. The concept was developed through interviews, notations, and making music while working together with folk music gurus at each site. The tunes were then translated, arranged and composed into pieces for a string quartet, but maintained the essence of the original ideas. Each piece in the set –Pang Ma Pha Suite, Resonance, Misty Town, and Recollection narrate the respective routes through the districts. Dissemination of this music was through live performances, a recorded music album, “Uplifting Tunes, Vivid Reminiscence, and Misty Town,” and Podcast tracks summarising the routes for travellers, available through digital streaming. The results showed that music can embrace the knowledge of archaeology, art history and history.