Increasing archaeological, fossil and genomic evidence indicate the presence of a range of extinct hominin species in Southeast Asia prior to the arrival of Homo sapiens to the region, including Homo erectus, Homo floresiensis, Homo luzonensis and, potentially, Denisovans. This diversity of hominin taxa is at odds with the stone artefact record of Southeast Asia, which tends to display a pattern of simplicity and continuity in reduction sequences and a general lack of formalised types. Explanations for this absence of change in the lithic record have focused largely on external factors that may have inhibited technological innovation or promoted an expedient or opportunistic approach to stone tool production and use. In this poster, we propose an alternative approach that examines the influence of hominin biomechanics on stone flake manufacture. It is possible that the general continuity of simple flake production in this region is in part caused by mechanical constraints imposed by hominin hand/wrist morphologies during stone knapping activities. We develop a new methodology to explore this hypothesis by combining musculoskeletal modelling with flintknapping experiments to clarify the relationships between hand/wrist anatomy and the knapping process, with a specific focus on the fossil morphologies of Homo floresiensis.