The Manila galleons sailed the Pacific for 250 years, bringing cargoes of luxury goods such as spices and porcelain to the Americas in exchange for New World silver. The route also fostered cultural exchanges that shaped the identities and culture of the countries involved: The Spanish Crown’s Viceroyalty of New Spain (today’s Mexico) and the Spanish East Indies (today’s Philippines). The ships made one or two round-trip voyages per year between the ports of Acapulco and Manila. While there is a reasonable and growing knowledge on the prestige objects and botanicals exchanged, the animals subject to translocation by the Manila galleons are poorly documented. The Zooarchaeology of the Galleon Trade Project (ZGTP), coordinated by the first and second authors of this abstract, aims to document the animal taxa translocated from Mexico to the Philippines and vice versa (e.g., pig, horse, goat, sheep, dog, turkey, goose, among others), as well as their uses, associated knowledge, and impact to the landscape of both regions. To address this, the ZGTP will combine the taxonomic and taphonomic study of faunal remains from several colonial-period archaeological sites and shipwrecks in the Philippines and Mexico with a review of historical written sources (i.e., chronicles, archives), stable-isotope analysis and archaeogenetics. Graduate students, under the supervision of the two coordinators, will be appointed in both countries to undertake some of the tasks, with the last author of this abstract being the first official recruit.